In the sequel, the Museum of Natural History is closed down for upgrading and the exhibits are put into storage at the Federal Archives in Washington, D.C. Amy Adams will play an undetermined historical figure who has a crush on security guard Larry (Stiller).

Security guard Larry Daley (Stiller) infiltrates the Smithsonian Institute in order to rescue Jedediah (Wilson) and Octavius (Coogan), who have been shipped to the museum by mistake

Watch Night at the Museum: Battle of the Smithsonian